C9400
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C9400
Sigma
Calcium Ionophore A23187 hemimagnesium salt
| Synonym: | A23187 hemimagnesium salt, Antibiotic A 23187 hemimagnesium salt, Calcimycin hemimagnesium salt, Calimycin hemimagnesium salt |
| CAS Number: | 72124-77-7 |
| Linear Formula: | C29H36Mg0.5N3O6 |
| Molecular Weight: | 534.77 |
| Beilstein Registry Number: | 6765085 |
| MDL number: | MFCD00151203 |
| PubChem Substance ID: | 24893158 |
Description
| Application | Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase. |
Properties
| storage temp. | 2-8°C |
Safety
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
References
| reference | Pressman, B.C., et al., Biological applications of ionophores. Annu. Rev. Biochem. 45, 50-530, (1976) |
| Kauffman, R.F., et al., Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. J. Biol. Chem. 255, 2735-2739, (1980) | |
| Markram, H., and Segal, M., Calcimycin potentiates responses of rat hippocampal neurons to N-methyl-D-aspartate. Brain Res. 540, 322-324, (1991) | |
| Knowles, R.G., and Moncada, S., Nitric oxide as a signal in blood vessels. Trends Biochem. Sci. 17, 399-402, (1992) |
